Abstract : In the present study the selected plant extracts and polyherbal mixture (PHM) were screened for their antihyperglycemic potential and thereby for their possible role in inhibition of the pathways leading to diabetic complications in STZ induced diabetic rats. Three herbs namely fruit pulp of Citrullus colocynthis (CC), leaves of Stevia rebaudiana (SR), and leaves of Swertia Chirayata (SC). Initially hypoglycemic studies were conducted without inducing of diabetes mellitus. Based on the results obtained PHM was prepared. The extracts which are showing % reduction of glucose between 30 -50% were selected in order to avoid hypoglycemic shock. All the selected plant extracts and PHM were found to decreased glucose levels at 3rd and 8th hrs and standard drug was found to decrease glucose levels at 1st & 6th hr significantly after every week (biphasic reduction). All the selected plant extracts and PHM were found to increase insulin levels at 3rd and 8th hrs and standard drug was found to increase levels at 1st & 6th hr significantly after every week (biphasic reduction).PHM was found to most potent.
Keyword : Diabetes mellitus, Diabetic complications, Citrullus colocynthis, Stevia rebaudiana, Swertia Chirayata, Polyherbal mixture (PHM)