Abstract : Rice is a major food and energy source of more than half the world population. The grain is a major source of carbohydrate and even protein. There are a number of varieties grown in Kerala having high medicinal value. However, rice is a poor source of essential micronutrients such as Fe and Zn. Micronutrient malnutrition, and particularly Fe and Zn deficiency affect over three billion people worldwide, mostly in developing countries. Biofortification through breeding and genetic engineering is the best tool to enhance the iron and zinc content of rice to meet the problem of malnutrition and dietary supplementation.
Abstract : Fast dissolving tablets are gaining prominence as new drug delivery systems. Here, in this study venlafaxine HCl is taken as the model drug to convert in to fast dissolving tablet using combination of natural disintegrating agent. Venlafaxine HCl is commonly used as antidepressant, has poor bioavailability due to extensive first pass metabolism. The aim of the study is to fast relief against the depression. The fast dissolving tablet was prepared by various natural disintegrating agent like Treated agar and Isapghula husk powder. A 32 Full Factorial Design was applied to investigate the combine effect of Treated agar and Isapghula husk powder. Disintegrating time, wetting time and in vitro drug release taken as response variables. The prepared tablets were evaluated for in vitro dissolution, friability, hardness and weight variation. All blends were compatible by evaluating them on FTIR study. No drug-excipients interaction was found. Tablets were showing faster disintegration within seconds and Statistic analysis software showed that batch FB10 was found to be optimized as it had almost identical dissolution profile. Optimized batch FB10 was conducted at accelerated conditions for one month and it was found to be stable.
Keyword : Isapghula husk, Fast dissolving tablets, Venlafaxine HCl
Abstract : The Aim of the present investigation was to formulate and evaluate Valsartan transdermal drug delivery system. A 32 full factorial design was employed to explore the effects of HPMC K4M and Polyvinyl Pyrrolidine (independent variables) on Tensile strength, % cumulative drug release at 6 hours and % cumulative drug release at 24 hours(Dependent variables). Drug-polymer compatibility studies was determined by Fourier Transform Infrared Spectroscopy. The result of compatibility study revealed that there was no interaction between drug and polymers. Results showed drug release in the range 78.73± 0.38 - 96.32±0.33 and drug content in the range of 95.49±0.444 - 98.40 ±1.21. Moisture content and moisture uptake were increased for patches containing higher amount of HPMC K4M. Patch containing HPMC K4M in higher proportion gives increase in the drug release. It indicates that as PVP K30 increase drug release was decreased. On the basis of In-Vitro drug release performance F9 was selected as the optimized formulation. Ex-vivo drug release study carried out for optimized batch and it showed 96.32±0.33 % drug release after 24 hours. F9 shows ideal higuchi release kinetic. Skin irritation study for F9 revealed that it was free of irritation. Optimized batch F9 was found to the stable at 40 ± 0.5 °C and 75 ± 5% RH during the test period of 1month.
Abstract : A simple, rapid, precise and reliable RP-HPLC method was developed for estimation of Voglibose (VOG) and Mitiglinide calcium hydrate (MGN) in pharmaceutical dosage form. The method is based of precolumn derivatization of Voglibose with 9-Fluorenylmethyloxycarbonyl chloride (FMOC - chloride) due to lack of chromophoric group it cannot directly estimated by UV detector in RP-HPLC method. Precolumn derivatization (PCD) conditions were optimized by evaluating the parameters such as concentration of borate buffer, concentration of FMOC-Cl and reaction time of derivatization. The chromatographic separation was achieved on Cosmosil BDS C18 (15 cm × 0.46 cm id, 5µm particle size) column using phosphate buffer (pH 4.0) and methanol (30:70) as mobile phase. Detection was carried out at 233 nm using UV detector. The retention time of Voglibose and Mitiglinide calcium hydrate were found to be 5.233 min and 3.580 min respectively. The developed method was validated for parameters such as accuracy, precision, linearity and solution stability.
Abstract : Herbal medicine is one of the oldest forms of medical treatment in human history and could be considered one of the forerunners of the modern pharmaceutical trade. Plants that have medical uses can be found growing in many settings all over the world. Iran with 1.64 million km2 areas has 7500-8000 plant species. Iran is an ancient country in usage of herbal plants. The ancient Persians soon became familiar with various medicinal plants. Several medicinal species are cultivated in Iran. This review focuses on some of these plants such as Ziziphora, Stachys, Satureja, Thymus, Scrophularia, Thymbra, Tanacetum, Ocimum and Crocus. Herbal medicine treats disease and promotes health with plant material. For centuries, herbal medicines are the primary methods to administer medicinally active compounds. Use of naturally occurring substances, usually of plant origin, in the prevention and treatment of disease, Western herbal medicine is based on the use of botanicals commonly available in North America and Europe. Herbal medicine is the study and use of medicinal properties of plants. We show that About three hundred Stachys species are reported; 34 of them are found in Iran, of which 13 are endemic. Several Stachys species are used in Iranian folk medicine as medicinal plants. In addition, pharmacological studies confirmed that extracts or components of plants belonging to the genus Stachys exert significant antibacterial, anti-inflammatory, antitoxic and antianoxia effects The present total species diversity index H represent that plants belonged that 71 1.27 species, 41families.Cultivated crops have 24 species 2.40 and 11 families. The weeds had 57 species 1.51 and 23 families. The birds had 37 species 1.89 and 24 families, other aquatic faunal species 17 2.66 and 16 families. In the biodiversity of semnan iran was decreasing day by day. Agricultural crops and other aquatic fauna were listed maximum but plants, and weeds diversity index were minimum.